The ambition of the VIB Center for Cancer Biology (CCB) is to contribute to a better understanding of the biology that underlies cancer initiation, progression and metastatic dissemination with the ultimate goal to develop more effective and specific anti-cancer (combination) therapies.
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Acetyl-CoA at the crossroads of cell metabolism, signaling and epigenetics
A major current focus of the lab is to elucidate the mechanisms through which ATP-citrate lyase (ACL) regulates acetylation and its impact on signaling and gene expression, using cancer and metabolic cell types and mouse models. A second area of interest is in understanding the role of the hexosamine biosynthetic pathway in regulating metabolism and growth, and how the hexosamine biosynthetic pathway is regulated in cancer cells and its impact on cancer cell growth and proliferation.
• Wellen KE*, et al. ATPcitrate lyase links cellular metabolism to histone acetylation. Science. 2009 May, 22; 324(5930):1076-80. (*equal contribu:on)**.
• Lee JV, et al., and Wellen KE. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation, Cell Metab; 2014 Aug 5;20(2):306-19.
• Shah S et al. and , Wellen KE. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLYAMPK-AR feedback mechanism, Oncotarget, 2016, In Press