The ambition of the VIB Center for Cancer Biology (CCB) is to contribute to a better understanding of the biology that underlies cancer initiation, progression and metastatic dissemination with the ultimate goal to develop more effective and specific anti-cancer (combination) therapies.
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Revolutionary new insights into blood vessel formation in cancer | Research opens new avenue for cancer therapy
Blood vessel formation (angiogenesis) plays an important role in the development of various diseases, including cancer. The so-called anti-angiogenic treatments that counteract blood vessel formation are currently used in the treatment of cancer. However, these treatments are less efficient than we would like and cancer cells manage to bypass these treatments. Peter Carmeliet and Sarah-Maria Fendt (VIB/ KU Leuven) have discovered a new strategy to counteract blood vessel formation, based on their research which, in contrast to all expectations, indicates that fatty acid breakdown is essential in the creation of new blood vessels. They also provide a tangible new proposal for anti-angiogenesis treatments: namely blocking the enzyme CPT1a. These results are so innovative and ground-breaking that they are published as a Full Article in the leading journal Nature, accompagned by a News & Views.
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