Comment article in Nature Reviews Immunology by L.A Teuwen, V. Geldhof, A. Pasut & P. Carmeliet

COVID-19: the vasculature unleashed

On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection and inflammatory changes and propose novel therapeutic strategies.