Selected Publications

Cellular Metabolism and Metabolic Regulation

2020

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy - Sarah-Maria Fendt, Christian Frezza and Ayelet Erez - 2020 - CANCER DISCOVERY - Pubmed

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1 - Christensen, Emily M.; Bogner, Alexandra N.; Vandekeere, Anke; Tam, Gabriela S.; Patel, Sagar M.; Becker, Donald F.; Fendt, Sarah-Maria; Tanner, John J. - 2020 - Journal of Biological Chemistry - Pubmed

Nutrient metabolism and cancer in the in vivo context: A metabolic game of give and take - Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt - 2020 - EMBO reports - Pubmed

Cancer cells stock up in lymph vessels to survive - Barbara M Grüner, Sarah-Maria Fendt - 2020 - NATURE - Pubmed

Age-induced accumulation of methylmalonic acid promotes tumour progression - Gomes, Ana P.; Ilter, Didem; Low, Vivien; Endress, Jennifer E.; Fernandez-Garcia, Juan; Rosenzweig, Adam; Schild, Tanya; Broekaert, Dorien; Ahmed, Adnan; Planque, Melanie; Elia, Ilaria; Han, Julie; Kinzig, Charles; Mullarky, Edouard; Mutvei, Anders P.; Asara, John; de Cabo, Rafael; Cantley, Lewis C.; Dephoure, Noah; Fendt, Sarah-Maria; Blenis, John - 2020 - NATURE - Pubmed

Pyrvinium pamoate induces death of triple-negative breast cancer stem-like cells and reduces metastases through effects on lipid anabolism. - Dattilo, Rosanna; Mottini, Carla; Camera, Emanuela; Lamolinara, Alessia; Auslander, Noam; Doglioni, Ginevra; Muscolini, Michela; Tang, Wei; Planque, Melanie; Ercolani, Cristiana; Buglioni, Simonetta; Manni, Isabella; Trisciuoglio, Daniela; Boe, Alessandra; Grande, Sveva; Luciani, Anna Maria; Iezzi, Manuela; Ciliberto, Gennaro; Ambs, Stefan; De Maria, Ruggero; Fendt, Sarah-Maria; Ruppin, Eytan; Cardone, Luca - 2020 - Cancer research - Pubmed

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis - Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M Winkelkotte, Carina R Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F Orth, Thomas G P Grünewald, Almut Schulze, Sarah-Maria Fendt - 2020 - Cell Rep - Pubmed

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization - Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, Tong Tong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock - 2020 - Cell Metabolism - Pubmed

Glutamine Metabolism Controls Chondrocyte Identity and Function - Steve Stegen, Gianmarco Rinaldi, Shauni Loopmans, Ingrid Stockmans, Karen Moermans, Bernard Thienpont, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet - 2020 - Developmental Cell - Pubmed

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. - Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt S-M, Zanivan S, Leung HY - 2020 - Nat Commun - Pubmed